IMPACT OF COMPREHENSIVE GENOMIC PROFILING NGS PANELS IN PRECISION ONCOLOGY: THE CITY OF HOPE CMDL EXPERIENCE

The City of Hope (COH) Comprehensive Cancer Center provides a multidisciplinary, collaborative environment where basic, clinical, and translational research intersect is recognized as one the leaders in cancer treatment. COH Clinical Molecular Diagnostic Laboratory (CMDL) has been pioneer molecular diagnostics with over twenty years clinical experience both somatic germline testing. CMDL offering multiple next generation sequencing (NGS)-based comprehensive genomic profiling panels, HopeSeq Panels, for many to guide clinicians diagnosis, prognosis, therapeutic strategies treatment by providing expanded coverage trials gene targets which are recommended cited professional organizations including World Health Organization (WHO), European Leukemia Net (ELN), National Network (NCCN) Society Medical Oncology (ESMO). Being designated laboratory NCI-ComboMATCH study Institute (NCI), these panels have strengthened COH’s leading position further its provider Precision Oncology. profiles each patient reviewed daily multidisciplinary tumor board meetings an expert team includes pathologists, geneticists, hematopathologists prior reporting ensure variants appropriately classified based on AMP/ACMG guidelines context patient’s cancer.